Analysis of DNA-nanorobot joint
DNA nanostructures are increasingly used for the realization of mechanically active nanodevices and
DNA-based nanorobots. A fundamental challenge in this context is the design of molecular machine
elements that connect the rigid structural components and are powered in an effective way. Here we
investigate a pivot joint that enables rotational motion of a nanorobotic arm and show the storage
and release of mechanical energy by winding up and relaxing the joint that functions as a molecular
torsion spring. Using electrical manipulation of the nanorobotic arm and simultaneous observation
via single molecule fluorescence microscopy, we study the mechanical properties of various joint
designs. Brownian dynamics simulations suggest that breaking of stacking interactions is a major
contributor to enthalpic energy storage. Link to paper